RapamycinFungusV1, Main, Exploration, bibRecord, 000233

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

Identifieur interne : 000233 ( Main/Exploration ); précédent : 000232; suivant : 000234

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

Source :

Cellular & molecular immunology [ 2042-0226 ] ; 2019.

RBID : pubmed:30705387

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), B-Lymphocytes (cytology), B-Lymphocytes (immunology), B-Lymphocytes (metabolism), Carrier Proteins (physiology), Cell Proliferation (MeSH), Cells, Cultured (MeSH), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 1 (metabolism), Mechanistic Target of Rapamycin Complex 2 (genetics), Mechanistic Target of Rapamycin Complex 2 (metabolism), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Phosphorylation (MeSH), Proto-Oncogene Proteins c-myc (genetics), Proto-Oncogene Proteins c-myc (metabolism), Signal Transduction (MeSH).
MESH :
- chemical , genetics : Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Proto-Oncogene Proteins c-myc.
- chemical , metabolism : Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Proto-Oncogene Proteins c-myc.
- chemical , physiology : Carrier Proteins.
- cytology : B-Lymphocytes.
- immunology : B-Lymphocytes.
- metabolism : B-Lymphocytes.
- Animals, Cell Proliferation, Cells, Cultured, Mice, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Signal Transduction.

Abstract

Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody responses, and anti-viral immunity. At the molecular level, Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2, respectively. Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.

DOI: 10.1038/s41423-018-0185-x
PubMed: 30705387
PubMed Central: PMC6804816

Affiliations:

République populaire de Chine, États-Unis

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to stream Main, to step Corpus: 000354
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Le document en format XML

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<author><name sortKey="Liu, Dou" sort="Liu, Dou" uniqKey="Liu D" first="Dou" last="Liu">Dou Liu</name>
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<author><name sortKey="Huang, Chuanxin" sort="Huang, Chuanxin" uniqKey="Huang C" first="Chuanxin" last="Huang">Chuanxin Huang</name>
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<author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name>
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<author><name sortKey="Li, Fubin" sort="Li, Fubin" uniqKey="Li F" first="Fubin" last="Li">Fubin Li</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.</title>
<author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name>
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<author><name sortKey="Lazorchak, Adam S" sort="Lazorchak, Adam S" uniqKey="Lazorchak A" first="Adam S" last="Lazorchak">Adam S. Lazorchak</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Ouyang, Xinxing" sort="Ouyang, Xinxing" uniqKey="Ouyang X" first="Xinxing" last="Ouyang">Xinxing Ouyang</name>
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</author>
<author><name sortKey="Zhang, Huihui" sort="Zhang, Huihui" uniqKey="Zhang H" first="Huihui" last="Zhang">Huihui Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Liu, Hongzhi" sort="Liu, Hongzhi" uniqKey="Liu H" first="Hongzhi" last="Liu">Hongzhi Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arojo, Omotooke A" sort="Arojo, Omotooke A" uniqKey="Arojo O" first="Omotooke A" last="Arojo">Omotooke A. Arojo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520</wicri:regionArea>
<wicri:noRegion>06520</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan, Lichong" sort="Yan, Lichong" uniqKey="Yan L" first="Lichong" last="Yan">Lichong Yan</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jin, Jingsi" sort="Jin, Jingsi" uniqKey="Jin J" first="Jingsi" last="Jin">Jingsi Jin</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Han, Yuheng" sort="Han, Yuheng" uniqKey="Han Y" first="Yuheng" last="Han">Yuheng Han</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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</affiliation>
</author>
<author><name sortKey="Qu, Guojun" sort="Qu, Guojun" uniqKey="Qu G" first="Guojun" last="Qu">Guojun Qu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fu, Yuhong" sort="Fu, Yuhong" uniqKey="Fu Y" first="Yuhong" last="Fu">Yuhong Fu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Xiaocao" sort="Xu, Xiaocao" uniqKey="Xu X" first="Xiaocao" last="Xu">Xiaocao Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520</wicri:regionArea>
<wicri:noRegion>06520</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Xiaobo" sort="Liu, Xiaobo" uniqKey="Liu X" first="Xiaobo" last="Liu">Xiaobo Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Wenqian" sort="Zhang, Wenqian" uniqKey="Zhang W" first="Wenqian" last="Zhang">Wenqian Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Zhengfeng" sort="Yang, Zhengfeng" uniqKey="Yang Z" first="Zhengfeng" last="Yang">Zhengfeng Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruan, Chuan" sort="Ruan, Chuan" uniqKey="Ruan C" first="Chuan" last="Ruan">Chuan Ruan</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Wang, Qijun" sort="Wang, Qijun" uniqKey="Wang Q" first="Qijun" last="Wang">Qijun Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Dou" sort="Liu, Dou" uniqKey="Liu D" first="Dou" last="Liu">Dou Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520</wicri:regionArea>
<wicri:noRegion>06520</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Chuanxin" sort="Huang, Chuanxin" uniqKey="Huang C" first="Chuanxin" last="Huang">Chuanxin Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center and School of Basic Medical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Fubin" sort="Li, Fubin" uniqKey="Li F" first="Fubin" last="Li">Fubin Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. fubin.li@sjtu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. fubin.li@sjtu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025</wicri:regionArea>
<wicri:noRegion>200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. bingsu@sjtu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA. bingsu@sjtu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<series><title level="j">Cellular & molecular immunology</title>
<idno type="eISSN">2042-0226</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>B-Lymphocytes (cytology)</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (metabolism)</term>
<term>Carrier Proteins (physiology)</term>
<term>Cell Proliferation (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Proto-Oncogene Proteins c-myc (genetics)</term>
<term>Proto-Oncogene Proteins c-myc (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Lymphocytes B (cytologie)</term>
<term>Lymphocytes B (immunologie)</term>
<term>Lymphocytes B (métabolisme)</term>
<term>Phosphorylation (MeSH)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Protéines de transport (physiologie)</term>
<term>Protéines proto-oncogènes c-myc (génétique)</term>
<term>Protéines proto-oncogènes c-myc (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Souris knockout (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
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<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Proto-Oncogene Proteins c-myc</term>
</keywords>
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<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Proto-Oncogene Proteins c-myc</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>B-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Protéines proto-oncogènes c-myc</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Lymphocytes B</term>
<term>Protéines proto-oncogènes c-myc</term>
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<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Phosphorylation</term>
<term>Prolifération cellulaire</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
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<front><div type="abstract" xml:lang="en">Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody responses, and anti-viral immunity. At the molecular level, Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2, respectively. Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30705387</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2042-0226</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<Issue>9</Issue>
<PubDate><Year>2019</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Cellular & molecular immunology</Title>
<ISOAbbreviation>Cell Mol Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.</ArticleTitle>
<Pagination><MedlinePgn>757-769</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41423-018-0185-x</ELocationID>
<Abstract><AbstractText>Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody responses, and anti-viral immunity. At the molecular level, Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2, respectively. Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Man</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lazorchak</LastName>
<ForeName>Adam S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>EMD Serono Research & Development Institute, Inc., 45 Middlesex Tpke, Billerica, MA, 01821-3936, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ouyang</LastName>
<ForeName>Xinxing</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
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   |texte=   Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

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